Scientific Publications of Associate Dr. Binia Drung

B. Drung, C. Scholz, V. A. Barbosa, A. Nazari, M. H. Sarragiotto, B. Schmidt, Computational & experimental evaluation of the structure/activity relationship of ß-carbolines as DYRK1A inhibitors, ioorganic & Medicinal Chemistry Letters, 2014, 24, 20, 4854.

K. Harmrolfs, L. Mancuso, B. Drung, F. Sasse, A. Kirschning, Preparation of new alkyne-modified ansamitocins by mutasynthesis, Beilstein Journal of Organic Chemistry, 2014, 10, 535-543.

Q. Xiao, F. Zhang, G. Grassia, Y. Hu, Z. Zhang, Q. Xing, X. Yin, M. Maddaluno, B. Drung, B. Schmidt, P. Maffia, A. Lalenti, M. Mayr, Q., Xu, S. Ye, Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation, Arteriosclerosis, Thrombosis and Vascular Biology, 2014, 34, 90-98.

Q. Xiao, F. Zhang, L. Lin, C. Fang, G. Wen, T.-N. Tsai, X. Pu, D. Sims, Z. Zhang, X. Yin, B. Thomaszewski, B. Schmidt, M. Mayr, K. Suzuki, Q. Xu, S. Ye, Functional Role of Matrix Metalloproteinase-8 in Stem/Progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions, Circulation Research, 2013, 112, 35-47.

A. M. Cooper, P. S. Hobsen, M. R. Jutton, M. W. Kao, B. Drung, B. Schmidt, D. J. Fear, A. J. Beavil, J. M. McDonnell, B. J. Sutton, H. J. Gould, Soluble CD23 Controls IgE Synthesis and Homeostasis in Human B Cells, The Journal of Immunology, 2012, 188, 7, 3199-3207.

V. Lo Sardo, C. Zuccato, G. Gaudenzi, B. Vitali, C. Ramos, M. Tartari, M. A. Myre, J. A. Walker, A. Pistocchi, L. Conti, M. Valenza, B. Drung, B. Schmidt, J. Gusella, S. Zeitlin, F. Cotelli, E. Cattaneo, An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin, Nature Neuroscience, 2012, 15, 5, 713-721.

A. Zall, D. Kieser, N. Höttecke, E. C. Naumann, B. Thomaszewski, K. Schneider, D. T. Steinbacher, R. Schubenel, S. Masur, K. Baumann, B. Schmidt, NSAID-derived ?-secretase modulation requires an acidic moiety on the carbazole scaffold, Bioorganic & Medicinal Chemistry, 2011, 19, 4903-4909.

T. Knobloch, K. Harmrolfs, F. Taft, B. Thomaszewski, F. Sasse, A. Kirschning, Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-Oriented Approach to Exploit Biosynthetic Flexibility, Chem Bio Chem, 2011, 11, 4, 540-547.

Scientific Publications of Associate Joshua Price

L. Lercher, R. Raj, N. A. Patel, J. Price, S. Mohammed, C. V. Robinson, C. J. Schofield, B. G. Davis, Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation, Nature Communications, 2015, 6, 7978.

Scientific Publications of Associate Dr. Sebastian Stephan

S.Stephan, N. Kaul, undH. Villinger. Validation of impact penetrometer data by conepenetration testing and shallow seismic data within the regional geology of theSouthern North Sea. Geo-Marine Letters, 35(3):203–219, 2015.

H. W. Villinger, T Pichler, N. Kaul, S. Stephan,H. Pälike, und F. Stephan. Formation of hydrothermal pits in the GuatemalaBasin (Equatorial East Pacific) and the role of seamounts from heat flow andseismic studies. Submitted toGeochemistry, Geophysics, Geosystems,2015.

F.Schmidt-Schierhorn, N. Kaul, S. Stephan, und H. Villinger. Geophysicalsite survey results from North Pond (Mid-Atlantic Ridge). In Proceedings ofthe Integrated Ocean Drilling Program, Volume 336, 2012.

S. Stephan, N. Kaul, undH. Villinger. The Lance Insertion Retardation meter (LIRmeter): an instrumentfor in situ determination of sea floor properties—technical description andperformance evaluation. Marine Geophysical Research, 33:209–221, 2012.

S. Stephan, N. Kaul, N. Stark,H. Villinger, und T. Wever. LIRmeter: A new tool for rapid assessment of seafloor parameters. Bridging the gap between free-fall instruments andframe-based CPT. Proceedings MTS/IEEE OCEANS 2011 Kona, 2011.

Scientific Publications of Associate Dr. Nadine Hätscher

Patrizia Malkomes,Ilaria Lunger, Alexander Luetticke, Elsie Oppermann, Nadine Haetscher, Hubert Serve, Katharina Holzer, Wolf OttoBechstein, Michael A. Rieger, SelectiveAKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells.Ann Surg Oncol (2016) 23: 2849.doi:10.1245/s10434-016-5218

WingertS., Thalheimer F.B., Haetscher N.,Rehage M., Schroeder T., and Rieger M.A., TheDNA-damage response gene GADD45A induces differentiation in hematopoietic stemcells without inhibiting cell cycle or survival. Stem Cells; 01/2016; DOI:10.1002/stem.2282

Nadine Haetscher*, Yonatan Feuermann*, SusanneWingert, Maike Rehage, Frederic Thalheimer, Christian Weiser, HanibalBohnenberger, Klaus Jung, Timm Schroeder, Hubert Serve, Thomas Oellerich,Lothar Hennighausen, Michael A. Rieger, STAT5-regulatedmicro-RNA-193b controls haematopoietic stem and progenitor cell expansion bymodulating cytokine receptor signaling. Nat.Commun.; 11/2015; DOI: 10.1038/ncomms9928

Frederic B. Thalheimer,Susanne Wingert, Pangrazio De Giacomo, Nadine Haetscher, MaikeRehage, Boris Brill, Fabian J. Theis, Lothar Hennighausen, Timm Schroeder,Michael A. Rieger, Cytokine-Regulated GADD45G Induces Differentiation andLineage Selection in Hematopoietic Stem Cells. Stem Cell Reports,2014 Jun 19;3(1):34-43. doi: 10.1016/j.stemcr.2014.05.010

*FeuermannY., *Kang K., *Gavrilova O., *Haetscher N., Jin Jang S., Yoo K.H., Changtao J., Gonzalez F., Robinson G. W., and Hennighausen L., MiR-193band miR-365-1 are not required for the development and function of brown fat inmice. RNA Biol.; 12/2013; 1;10(12):1807-14.; doi: 10.4161/rna.27239

Eißmann M, Melzer IM,Fernández SB, Michel G, Hrabě de Angelis M, Hoefler G, Finkenwirth P, Jauch A,Schoell B, Grez M, Schmidt M, Bartholomae CC, Newrzela S, Haetscher N,Rieger MA, Zachskorn C, Mittelbronn M, Zörnig M., Overexpression of theanti-apoptotic protein AVEN contributes to increased malignancy inhematopoietic neoplasms. Oncogene; 05/2013; 16;32(20):2586-91; doi:10.1038/onc.2012.263

GlockerEO*, Kotlarz D*, Boztug K*, Gertz EM, SchäfferAA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N.,Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C,Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S,Snapper SB, Grimbacher B, Klein C., Inflammatorybowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med.;11/2009; 19;361(21):2033-45; doi: 10.1056/NEJMoa0907206